| Worm gene | Human gene | Description | Team | Media |
| lin-35 | Rb | Retinoblastoma occurs in early childhood and affects about 1 child in 20,000. Tumors develop from the immature retina (the part of the eye... more | Matthew Allen |
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| epi-1 | LAMA3 | This project is still in progress. Check back for results. | Matthew Allen Joseph Chong Kay Gamble |
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| K02D7.1 | NP | Nil | Toh Pee Li Leslie |
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| XK675 | CBS | Homocystinuria is an autosomal recessive disorder of methionine metabolism. Cystathione beta synthase (CBS) is the human gene product that catalyzes... more | Philip Jeffery |
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| rnt-1 | RUNX1 | The protein encoded by the human gene represents the alpha subunit of Core Binding Factor (CBF) and is thought to be involved in the development of... more | Alyson Downing |
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| C31E10.7 | CYB5A | PCR has been done for the designed primers; no transformation has been done yet. | Karen Tiffany |
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| H37A05.1 | LPIN-2 | (OMIM:605518), LPIN2 (OMIM:605519, mutated in Majeed syndrome), and LPIN3 (OMIM:605520); H37A05.1 is expressed in vulval muscle; in mass RNAi assays... more | Kay Gamble |
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| C53D5.5 | GGT-1 | In humans the enzyme gamma-glutamyl transpeptidase is used in the catabolism of glutathione. It is found on the outer surface of the cell membrane... more | Denise Williams |
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| sec-23 | SEC23A | This gene when repressed by RNAi causes maternal sterility, embryonic lethality, abnormal protein subcellular localization, molting defects, and... more | Billie Conway Randy Dix Susan Groff Toh Pee Li Leslie Lauren Turner Cathy Williamson |
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| ncr-1 | NPC1 | Expression of ncr-1 gene is widespread and involves the distribution pattern of cholesterol in various tissues of C. elegans. It was chosen because... more | Ada Harvey Clement Ong Sanjeed V.K. Zoe Welsh |
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| K02D10.5 | SNAP29 | The experiment is incomplete, but at this time, PCR has been done. | Ada Harvey Zoe Welsh |
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| pabp-2 | pabpn1 | opmd is characterized by late-onset eyelid drooping, difficulty swallowing. as the disease progresses there is tongue atrophy and weakness.In some... more | lisa sakol |
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| him-6 | BLM | Phenotype is developmentally delayed (very extended life cycle time), numerous round rather than ovoid embryos but lack of expected number of larvae... more | Denise Williams Wendy Wooten lisa sakol |
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| KO2D7.1 | NP | the gene has been inserted into L4440 and transformed into DH5-alpha E.coli cells. I have also plated this transformed cells for future studies under... more | Joseph Chong |
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| C09G5.8 | RPGRIP1 | None | Cathy Williamson |
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| fum-1 | Fumarate hydratase | Fumarase, or fumarate hydratase (FH), is an enzyme involved in the Krebs cycle, where it catalyzes the formation of L-malate from fumarate. We... more | Alyson Downing Ray Lewis Karen Tiffany |
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| epi-1 | LAMA3 | epi-1 encodes an extracellular laminin. We constructed a feeding vector using the noted gene-specific primers and transformed this vector into the... more | Susan Groff |
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| col-39 | ectodysplasin A | There are more than 150 clinically distinct hereditary syndromes in which ectodermal dysplasia is present. Most syndromes are very rare and manifest... more | robert Ross |
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| ncr1 | npc1 | Niemann-Pick type C (NPC) disease is an autosomal recessive lipid storage disorder characterized by progressive neurodegeneration. Approximately 95%... more | Din-Pow Ma |
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| ATM-1 | ATM | Ataxia T is an autosomal recessive human disease that causes immune defects, predisposition to canacer & supersensitivity to ionizing radiation. AT... more | Shahira Badran |
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| D2023.5 | MPT- mercaptopyruvate sulfur transferase | Mercaptopyruvate sulfur transferase transfers sulfur ion from 3' sulfur of mercaptopyruvate to a variety of acceptors. Physiological acceptor is... more | David Wing |
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| hex-1 | HEXA | Tay-Sachs disease is a rare inherited disorder that causes progressive destruction of nerve cells in the brain and spinal cord. More than 100... more | Susan Gingold |
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| egl-15 | FGRF3 | Achondroplasia is an autosomal dominant disorder characterized by abnormal bone growth that results in short stature with disproportionately short... more | Kevin Hansen |
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| ubc-20 | huntingtin | Huntington's disease is an autosomal dominant disorder that typically appears beginning in mid-life. An ortholog in C. elegans to one of the genes... more | Meg Rawls |
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| B0432.4 | UPC2 | The uncoupling protein plays a role in producing heat and burning calories by creating trails that allows dissipation of the proton electrochemical... more | Lender Luse |
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| nob-1 | NOB1 | nob-1 encodes a HOX protein, in the posterior paralog group in C. elegans. In yeast, nob-1 is required for proteasome function and RNA metabolism. | Sandra Thompson-Jaeger |
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| hmr-1 | Cadherin 1 | Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are... more | robert Ross |
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| cft-1 | cft-1 | Related to the gene that produces a transmembrane protein responsible for moving chloride across the cell membrane. | Lynda Miller |
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| ctb-1 | mitochondrial cytochrome b | There is some evidence to indicate that a defect in the gene encoding the mitochondrial electron transport protein, cytoshrome Ib, is involved in... more | mary ogilvie |
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| XPA-1 | XPA | Human gene XPA is one of the genes that when muatated cauases the disease Xeroderma Pigmentosum. This condition is charactierized by extreme... more | Jim Youngblom |
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| ape-1 | p53 | ape-1 refers to an apoptosis enhancer gene first discovered by Kuwabara. It encodes a 769 aa protein that induces apoptosis in the germline and... more | Tucker Crum |
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| pmp-4 | Right primer starts at 1121 and left primer starts at 1495. Both primers are 20 bases each. | Dr. Chandramouly Tummalapalli |
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| brc-1 | BRCA1 | brc-1 in C. elegan is closely related to BRCA1 in humans. BRCA1 causes an early onset breast and ovarian cancer. BRC-1 damage chromatin... more | Lender Luse |
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| unc-26 | GBA2 | Acid beta-glucocerebrosidase, also known as beta-glucosidase (GBA; EC 3.2.1.45), is a lysosomal enzyme that catalyzes the breakdown of the glycolipid... more | Din-Pow Ma |
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| DJ-1 | PARK7 | Parkinson's disease is a movement disorder characterized by loss of dopaminergic neurons. DJ-1 interacts with p53 in vivo and in vitro; it... more | Sandra Thompson-Jaeger |
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| cep-1 | TRP 53 | Right primer starts at 4044 and left primer starts at 4436. | Dr. Chandramouly Tummalapalli |
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| fasn-1 | p63 | This gene encodes a fatty acid synthase like human FASN (Omim:600212) and the protein might be a direct target of p53-like proteins. | Tucker Crum |
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| Y50D7A.10 | GMF-B | Glial maturation factor beta was first linked to differentiation of brain cells, and later shown to aid neural regeneration and limit proliferation... more | kevin lyon |
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| fbl-1 | fibrillin-1 | Marfan syndrome is a connective-tissue disorder inherited as an autosomal dominant trait. Approximately 25% of cases are caused by a spontaneous... more | Kevin Hansen |
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| APL-1 | APP (amyloid beta A4 precursor protein) | Twisted plaques are visible in the brains of people with Alzheimer's disease. This human gene produces the precursor protein that is found in the... more | Jim Youngblom |
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| F07h5.2 | SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotei | right primer start at 2 left primer start at 553 | mehdi moghbel |
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| T07D3.4 | fukutin | right primer start at 1608 left primer start 2342 | mehdi moghbel |
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| sir-2.1 | SIRT1 | In the news recently is hype about red wine as the new fountain of youth because of a human homolog of the worm and yeast protein product of this... more | Tucker Crum |
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| nlg-1 | neuroligin-3 | Autism spectrum disorder is a developmental disorder characterized by impaired social interactions & communication skills along with repetitive... more | Lisa German |
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| pat-2 | Platelet Glycoprotein IIb | Glanzman's thrombasthenia is characterized by increased clotting time due to a mutation in the GPIIb gene. Glycoprotein IIb and Glycoprotein IIa... more | mary ogilvie |
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| lin-35 (abnormal cell LINeage family member) | Retinoblastoma 1 | This genetic disease affects the eyesight of young children particularly below the age of 5. Cancerous cells originating from the eyes spread fast to... more | Ee Ling Tan |
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| C18H7 | von Willebrand factor and related coagulation proteins. A hemorrhagic condition in persons living on the Aland Islands in the Sea of Bothnia between... more | Jeanelle Hardwick |
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| hex-1 | N-acetyl-beta-glucosaminidase prepro-polypeptide | Tay sachs disease TSD is inherited in an autosomal recessive pattern. The disease occurs when harmful quantities of a fatty acid derivative called a... more | susan schylander |
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| ptl-1 | microtubule-associated protein tau isoform 5 (MAPT) | Wszolek et al. (1992) reported a large kindred in which 32 members in 8 generations had a neurodegenerative disorder characterized by progressive... more | Jordan Wolf |
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| ets-5- (ETS class transcription factor) | ets variant gene 1 | In humans, the mutation in the ets variant gene 1 causes the emergence of the disease Prostate Cancer that occurs in males with prevalent occurrence... more | Azahar Dahlan |
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| W03D8.8 | NP_689544 | Alzheimer's disease is a progressive, degenerative disease of the brain in which brain cells die and are not replaced. It results in impaired memory... more | Renee Leong |
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| lgc-37 | NP_775807 | Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or... more | kelly lewis |
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| unc-26 | 19q13.1, 7q31.2 | This is a gene involved in transporting chloride ions across cell membranes.Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a... more | Tom Freeman |
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| gtl-2 | 15q21 | "Amyotrophic lateral sclerosis-parkinsonsim/dementia complex of Guam is a neurodengenerative disorder with unusually high incidence among the... more | Brenda Royal |
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| dcr-1 | Dicer 1 | What happens if an extra copy of dicer is added to the genome? Does the silencer get silenced? | Jaak Raudsepp |
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| gene name N/A K07A12.2 locus = NP_492348 | P98161.2 | In humans: A number sign (#) is used with this entry because of evidence that polycystic kidney disease (PKD) may arise from mutations in any of... more | Sondra Stark |
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| N/A | ARMD4 (AGE-RELATED MACULAR DEGENERATION); COMPLEMENT FACTOR H | ARMD4: there is a significant association between ***polymorphism in the gene encoding complement factor H (CFH; 134370) and susceptibility to... more | David Barry |
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| Hex-1 | NP_000511.2 hexosaminidase A | Tay-Sachs is caused by the absence of the enzyme hexosaminidase-A (Hex-A). Without Hex-A, a lipid, called GM2 accumulates in cells, especially in the... more | lutz holzinger |
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| Collagen WormBase:WBGene00004300 | NP_536348 | #266600 INFLAMMATORY BOWEL DISEASE 1; IBD1 REGIONAL ENTERITIS CROHN DISEASE Inflammatory bowel disease is characterized by a chronic relapsing... more | Sherry Davis |
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| Y11B2A.8 | PRKAG2;062743 | WPW can be caused by a mutation in the gamma-2 regulatory subunit of AMP-activated protein kinase. Features: short PR interval and prolonged QRS on... more | Nancy Wyllie |
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| OSM-3 | KIF17 | This is all the information I could find at this time. | Ernest Archer |
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| pdr-1 (Parkinson's Disease Related) | human parkin (PARK2) | Parkinson's disease is a degenerating disease that affects the central nervous system. People affected by this disorder suffer from degeneration of... more | Azahar Dahlan Renee Leong Ee Ling Tan |
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| Col-135 | Col29A1 | Atopic Dermatitis or eczema is an inflammatory disease that begins early in life. Symptoms of eczema include inflammation in the epidermal layer of... more | Donna Drontle |
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| abl-1 | abl-1 | ABL-1 inhibits germline apoptosis induced by radiation or by natural aging, but it has no effect on apoptosis induced by starvation or by chemical... more | Jordan Wolf |
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| Lrk-1 | LRRK-2 (PARK 8) | LRRK2 is a gene identified in familial forms of Parkinson's disease (PD)and may be central to the pathogenesis of several major neurodegenerative... more | Kathryn Kehoe |
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| dys-1 | Dystrophin-associated muscular dystrophies range from the severe Duchenne muscular dystrophy (DMD) to the milder Becker muscular dystrophy (BMD... more | Carol Keyes |
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| spe-15 | MYO6 | The spe-15 gene encodes an unconventional myosin that is homologous to both Drosophila and mouse myosin VI; it also has homologues in many other... more | Brenda Leicht |
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| lmn-1 | lamin A | LMN-1 encodes the sole C. elegans nuclear lamin; LMN-1 protein is essential for the nuclear envelope localization of emerin (EMR-1) protein during... more | Karen Dalfrey |
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| daf-2 | Insulin receptor | C. elegans with defective daf-2 correspond to insulin resistance and Type II diabetes. | Georgia Hammond |
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| unc-32 | ATP6V0A2 | primers from e-rnai for this vacuolar ATPase gene subunit a2 The protein that it codes for moves from inside the cell to the surface of a subset... more | Kristy Shanahan |
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| Y42G9A.4 | Mevalonate kinase | This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid... more | Debra Hinson |
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| msh-2 | msh-2 | Cololrectal cancer is a major health issue. Several genes have been shown to be associated with hereditary non-polyposis colon cancer, including... more | Elizabeth Critser |
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| ugt-62 | UDP glucuronosyltransferase 1 family, polypeptide A1 | The human ortholog of the C. elegans ugt-62 gene is associated with an autosomal recessive genetic disorder in which bilirubin cannot be conjugated... more | Kevin Stilwell |
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| tag-144 | HPC1 | Prostate cancer is a common pathology of human males and is beginning to be understood on the genetic level. The worm ortholog of the human HPC1... more | William Yamokoski |
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| dpy-17 | NP_00384 | In humans, Ehlers-Danlos (E.D.) syndrome is a disorder affecting collagen V and produces symptoms in patients including looseness of joints, easily... more | Sandra Davis Mary Ritke |
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| T13C2.6 | VLDL receptor (very low density lipoprotein receptor) | Unertan syndrome has been discovered in a family in Turkey. Members of this family walk on all four limbs. The mutation maps to the VLDL receptor... more | Lark Claassen |
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| mrp-6 | CFTR | Source: OMIM Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a chloride channel and controls the regulation of other... more | Donna-Marie Gardner |
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| vha-6 | VPP1 (OMIM:192130) | vha-6 (vacuolar H ATPase) is orthologous to the VPP1 gene in humans. The VPP1 gene in humans causes distal renal tubular acidosis and osteopetrosis. | Nickie Cauthen |
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| mec-5 | alpha 2 type V collagen preproprotein | In humans, Ehlers-Danlos (E.D.) syndrome is a disorder attributed to mutations collagen V. Most persons with the Ehlers-Danlos syndrome are born... more | Sandra Davis Mary Ritke |
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| ttx-1 | Otx2 | In progress. | James Smith |
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| apr-1 | APC | Source: OMIM. "The APC gene encodes a multidomain protein that plays a major role in tumor suppression by antagonizing the WNT signaling pathway... more | Lark Claassen |
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| dys-1 | DMD | Duchenne Muscular Dystrophy is an X-linked disorder that causes progressive muscle degeneration. Onset of symptoms occurs between 2-5 years of age... more | Janet Baker |
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| dys-1 | DMD | The dys-1 gene encodes an ortholog of human DMD, which when mutated leads to Duchenne muscular dystrophy (OMIM:310200)or to the milder form Becker... more | Rebecca Ross |
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| F29B9.4 | c-fos | The AP-1 transcription factor is composed of members of the Fos and Jun DNA binding proteins families. AP-1 is involved in response to several... more | Deborly Wade |
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| PAH-1 | phenylalanine hydroxylase | Phenylketonuria (PKU) is an autosomal recessive inborn error of metabolism resulting from a deficiency of phenylalanine hydroxylase (EC 1.14.16.1)... more | Maggie Boylan |
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| hum-6 | MYO7A and MYO15A | hum-6 is orthologous to the human gene MYOSIN VIIA (MYO7A; OMIM:276903), which when mutated leads to Usher syndrome type IB. hum-6 is also... more | Shelley Acosta |
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| olrn-1 | na | Homolog of a Drosophila gene. | Katherine Bates |
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| pdi-2 | na | Protein disulfide isomerase | Katherine Bates |
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| Caenorhabditis elegans -dys 1 | dys 1 | The dys-1 gene encodes an ortholog of human DMD, which when mutated leads to Duchenne muscular dystrophy | Vimlarani Chopra |
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| lbp-5 | DHTR (dihydrotestosteron receptor) | Androgen insensitivity syndrome is a condition that affects sexual development before birth and during puberty. People with this condition are... more | Sanghamitra Mohanty |
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| F15D3.1a | DMD (dys-1) | Duchenne Muscular Dystrophy is an X-linked disorder that causes progressive muscle degeneration. Onset of symptoms occurs between 2-5 years of age... more | Vimlarani Chopra |
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| tsp-8 | Kangai-1; KAI-1 | tsp-8 is an orthologue to the human metastasis suppressor gene, Kangai-1, or KAI-1. The gene is a member of the tetraspanin superfamily of genes... more | Kevin Toal |
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| sma-2 | SMAD1 | SMAD1, the human homolog of the Drosophila gene MAD1 (Mothers Against Decapentaplegic 1), encodes a protein involved in the BMP (bone morphogenic... more | Janice Lai |
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| Col-135 | collagen type XXIX alpha 1 | Atopic dermatitis (eczema) exhibits a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry... more | Elizabeth Ramirez Garza |
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| let-60 | Ras | Ras is a family of proteins involved in cell signaling pathways that modulate cell growth and proliferation. Mutations in the Ras family(H-Ras... more | Angela Wheeler |
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| cua-1 | ATP7A | Menkes disease is an X-linked recessive mutation in a gene coding for a Cu(2+)-transporting ATPase. It results in copper deficiency which causes... more | Virginia Balke |
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| pxl-1 | paxillin | Neurofibromatosis type II is an autosomal dominant disorder (cancer) that results in tumors (schwannomas) in the nervous system. Loss of NF2 has... more | Kristen Johnson |
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| Lam1 | lamin gene | Lam 1 encodes nuclear lamin in C. elegans. This protein is required for nuclear envelope localization during early development since the protein... more | M. Elaine Cox |
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| Transketolase | BCKDHA | Maple syrup urine disease (MSUD) is an autosomal recessive disorder that is most prevalent among some Mennonite populations. There are several... more | Chris Barton |
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| SRC-1 | Her2/neu aka ERBB2 | HER2/neu aka ERBB2, Human Epidermal Growth Factor receptor 2, is a protein that gives higher aggressiveness in breast cancer. Y92H12A.1 is the C... more | Judith Coston |
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| clh-3 | CLC-2 | The worm gene clh-1 codes for a chloride channel. It is homologous to the human channel CLC-2. The CLC class of chloride channels/transporters are... more | Dan Hansen |
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| stn-2 | syntrophin | Iin C. elegans, this protein is associated with neurons and muscles, and is known to cause abnormal locomotion and head movements | Ray Hong |
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| ptl-1 | tau/MAP2/MAP4 | microtubule binding protein homologous to tau/MAP2/MAP4 associated with neurodegenerative disorders including Alzheimers and Picks Disease | Hope Johnson |
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| C46E1.3 | none | unknown gene with no known human homolog and known C. elegans RNAi or mutant phenotype | Ray Hong |
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| Let-29 | Protein Phosphatase 2A | PP2A is a ubiquitious protein phosphatase involved in a number of cellular processes. We are interested in its interaction with the cyanobacterial... more | Aparna Sreenivasan |
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| kpc-1 | Furin | Kex-2/furin like serine protease; other furin-like convertases are implicated in Notch and TGF-beta signaling pathways. | Alison Miyamoto |
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| dpy-28 | CNAP1 | This protein is involved in negative chromosome-wide regulation of X chromosome gene expression and is known to cause abnormalities in embryogenesis... more | Ray Hong |
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| sel-12 | presenelin (PS1) | transmembrane protein orthologous to presenilins, regulation of notch-like signaling pathways | Hope Johnson |
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| K10D6.4 | none | This gene has no homologs outside of nematodes and encodes for proteins with unknown function. There is no reported RNAi or mutant phenotype | Ray Hong |
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| ptp-2 | PTPN11 | Explore the effects of silencing this gene in c.elegans. The human disease is characterized by multiple lentigines, electrocardiographic conduction... more | Richard Johnston |
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| SIMILAR TO XERODEMA PIGMENTOSUM D | XPD | mutation leads to pre-natal developmental problems such as"larval arrest", "embryonic lethal", and post-natal problems such as "slow growth" and... more | Crima Pogge |
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| Leptin receptor gene-related protein | Ob-RGRP | Obesity is a major epidemic disease today. Genetic studies in mice models have revealed the leptin signaling pathway as a regulator of body weight... more | Nitika Parmar |
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| erm-1 | villin 2 (ezrin) | The ezrin protein encoded by the human villin-2 gene plays a role in signal transduction, cell motility, migration and metastasis. Ezrin is... more | Melissa Rowland-Goldsmith |
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| Peroxisome Proliferator-Activated Receptor gamma | Peroxisome Proliferator-Activated Receptor gamma | Key nuclear transcription factor that determines cell adipogenic differentiation and cell proiferation | Virender Rehan |
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| gspd-1 | G6PD | G6PD deficiency is a common metabolic disease with multiple genetic lesions leading to a range of clinical manifestations from anemia to hemolytic... more | Buran Haidar |
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| FRM-1 | TERT | erythrocyte membrane protein. Ortholog to hTERT gene for telomerase catalization. | Derrick Lavoie |
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| C05H8.1a | Calcium/calmodulin dependent protein kinase kinase 2 protein iso | Calcium/calmodulin dependent protein kinases play important role in calcium-mediated signal transduction pathway. One example of this is unc-43 in C... more | Sagarika Dash |
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| GFP within the GFP-marked C. elegans strain AZ235 | None | The project aims at silencing GFP expression in AZ235 using RNAi for visual assessment under UV microscope. | Buran Haidar |
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| apl-1 | APLP1 | This gene encodes an almost identical isoform orthologous to human APLP-1, the overexpression of which may cause abnormal locomotion, infertility... more | Xin Wen |
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| Prdx-2 | peroxiredoxin | explore the effect of silencing Prdx-2 on worms and its role in antioxidant defence against envionmental radiation. | tieli wang |
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| kin-2 | cAMP_dependent protein kinase | homolog of cAMP_dependent protein kinase specificity 51.34 efficiency 7 primer set #2 to silence single kinases that modify tyrosine hydroxylase... more | Susan Colette Daubner |
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| fcd-2 | Fanconi anemia complementation group D2 isoform b (homo sapiens) | cd-2 encodes an ortholog of the human gene FANCD2 (mutated in Fanconi anemia, OMIM:227646) that is strongly required for resistance to DNA... more | Wendy Jamison |
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| ftt-2 | 14-3-3 proteins: beta, delta, gamma, eta, zeta, tau, epsilon | probe specificity 51.39 efficiency 17.93 primer ranking 1 in vertebrates there are 7 isoforms of 14-3-3 protein, so there mayl be several targets... more | Susan Colette Daubner |
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| pat-2 | integrin alpha subunit | In C. elegans, pat-2 encodes alpha integrin subunit. This gene is essential for body wall assembly and function, hence proper development and... more | Susan Mechanic-Meyers |
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| C06H2.3 | HIF-1a (603348) | Interested in HIF (Hypoxia Induced Factor)-1 in humans that has been associated with Diebetes and other human diseases. It is a transcription factor... more | Ron Kaltreider |
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| cmd-1 | calmodulin | efficiency 41.24 primer ranking 2 to silence proteins that affect the activity of tyrosine hydroxylase TyrH. calmodulin-calcium kinase labels TyrH... more | Susan Colette Daubner |
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| cmk-1 | calmodulin calcium dependent protein kinase | probe specificity 100.00 efficiency 29.11 primer ranking 1 to silence proteins that affect the activity of tyrosine hydroxylase TyrH... more | Susan Colette Daubner |
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| F36H5.4 | dystrophin | muscular dystrophy is a genetic disease resulting from a deletion in group of genes associated with the production of normal muscle protein named... more | mohammed abbas |
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| let-23 | EGF-R | The EGF-R initiates many pathways within the cell including the Ras-Raf-MEK-ERK signaling system. Abnormal regulation of the pathway is known to... more | Steven Theroux |
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| mek-2 | ERK kinase, MEK kinase | efficiency 40.23 primer ranking 1 to silence single kinases that modify tyrosine hydroxylase to see how important phosphorylation is in vivo (C... more | Susan Colette Daubner |
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| WBGene00001442 | Fox03A | Forkhead transcription factors are associated with G2-M checkpoint regulations. In addition, higher levels of FOXO3A have been assoicated with... more | Ron Kaltreider |
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| hypothetical gene | Aryl-hydrocarbon receptor-interacting protein | This gene is associated with the vertebrate retina. However, C. elegans does not appear to have an homologous sensory structure. | Judith Ogilvie |
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| rskn-1 | RPS6KA3 | rskn-1 is a member of a multigene family that includes growth factor-regulated serine/threonine kinases. The human homologue RPS6KA3 is involved in... more | Lucia Vazquez |
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| Ceh-10 | vsx1 | This is a homeobox gene important for development of head and retina. | Judith Ogilvie |
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| ags-3 | pcp2 | This gene is associated with neurons in the retina and cerebellum of vertebrates. | Judith Ogilvie |
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| yop-1 | dp1l1 | this gene is highly conserved from yeast to human and is associated with vesicular transport. | Judith Ogilvie |
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| R02F2.8 | AUX1 (Arabidopsis thaliana) | plant gene on chromosome 2 amino acid transmembrane transporter | Kelly Barry |
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| emb-9 | Collagen, type II, Alpha -1 | emb-9 encodes the alpha-1 chain of Type IV basement membrane collagen most closely equivalent to human COL4A1 (OMIM:120130) on the basis of... more | Margaret Bahe |
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| lin-1 | ETS transcription factor | Lin-1 encodes a member of the highly conserved ETS transcription factor family. In C.elegans, LIN-1 is a negative regulator of vulval development... more | Patti Erickson |
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| ftn-2 | FTH1 | Hemochromatosis is called “iron overload disease” and is a highly underdiagnosed condition in that damage occurs years before any symptoms are... more | Deborah Taylor |
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| CCO-1 | COX5B | COX is involved in the electron transport chain and is associated with multiple human diseases. | Ron Kaltreider |
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| APC-1 | APC | Many colorectal cancers are caused by the autosomal dominant gene, adenomatous polyposis coli. This gene interferes with the Wnt signaling pathway in... more | Rosemary Ford |
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| Sod-1 | Sod-1 | A mutation in the S0D-1 in humans is associated with ALS. The mutation in the gene in the C. elegans worm is associated with a phenotypic expression... more | Alisa Petree |
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| F13B12.5 | Insulin | Insulin is required to bind to a cell surface receptor before glucose can enter the cells. Impaired or lack of insulin production results in type I... more | Ron McNeel |
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| daf-7 | TGFB-1 | This human gene has been shown to be associated with the production of keloid. I would like to see the phenotype in worms when this gene is knocked... more | Jocelyn Ramos |
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| unc-2 | CACNA1A | Mutations in this gene produce a defective alpha 1A subunit of the voltage-dependent calcium channel. Human mutations affect the nervous system... more | Elisabeth Kasckow |
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| dop-4 | DRD4 | A mutation in this gene produces a defective dopamine D2-like receptor that inhibits adenylyl cyclase. Human mutations are associated with attention... more | Elisabeth Kasckow |
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| ver-4 | VEGF | In humans, VEGF is a protein crucial to endothelial cell growth. When mutated, endothelial cells do not replicate sufficiently to keep blood vessels... more | Allison B. Jablonski |
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| mrp-1 | CF Transmembrane Conductance Regulator: ABC superfamily protien | mrp-1 encodes an ATP-binding cassette (ABC) transporter most closely related to the multidrug resistance-associated proteins; mrp-1 activity is... more | Joshua Stuart |
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| rnf-113 | Breast cancer 1 gene early onset isoform 5 | Human breast cancer 1 gene early onset isoform 5 blasted against C elegans database. RiNg finger protein family member was homologous based on a... more | Teresa Singleton |
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| skn-1 | Nrf2 | NRF2 has a hydrophilic N-terminal domain, followed by an acidic region with characteristics of a DNA activation domain, a central cnc homology region... more | Vanessa Fitsanakis |
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| PVF-1 | platelet-derived growth factor alpha isoform 2 preproprotein [Ho | In a study of chemokine expression in fibroblasts from patients with systemic sclerosis and controls, Galindo et al. (2001) found that systemic... more | Anastasia Smith |
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| Tyramine Beta Hydroxylase family member tbh-1 | Dopamine beta-hydroxylase | catalyzes the oxidative hydroxylation of dopamine to norepinephrine | Susan Lentz |
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| F53F4.10 (Hypothetical protein) | NADH-Ubiquinone Oxidoreductase Flavoprotein 2; NDUFV2 | Within the CNS, mitochondrial complex I deficiency appears to be confined to the substantia nigra. Evidence implicates the 24-kD subunit of... more | Vanessa Fitsanakis |
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| RIC-3 | hric3 | Ric-3 encodes novel highly charged protein with two transmembrane domains and extensive coiled-coil domains; Ric-3 necessary for maturation and... more | Betty Davidson |
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| egl-15 | FGFR-1 | Fibroblast growth factor receptor 1 (FGFR-1) is a tyrosine kinase regulating cell division. In some families, a mutation in FGFR-1 results in... more | Allison B. Jablonski |
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| rep-1 | rep-1 | Choroideremia (CHM) is an X-linked,recessive, degenerative disorder of the choroid and retina of the human eye. The known defect in most CHM cases is... more | Frances Weaver |
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| sli-1 | CBL | C. elegans has one ErbB gene, called let-23, which controls the amount of vulval tissue in these animals. In an analogous manner to the situation in... more | Sharla Martin |
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| let-60 | LOCUS AK292510 1418 bp | De novo designed RNAi primer using e-RNAi. This project deals with Pancreatic Acinar Carcinoma (OMIM 260350) Point mutations in codon 12 of the... more | Jorge Vasquez-Kool |
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| cua-1 | ATP7A | My best friend had to have a liver transplant due to a copper transport disease (Wilsons disease) and this gene was closely related in C. elegans | Richard Vestal |
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| smf-3 | NRAMP1 | Score = 535 bits (1377), Expect = 2e-151, Identities = 286/553 (51%), Positives = 371/553 (67%), Gaps = 24/553 (4%) | Hamid Mukhtar |
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| ace-1 | NLGN3 (Neuroligin-3) | Asperger's syndrome is a mild variant of autism spectrum disorder. A number of possible gene candidates for familial forms of the disorder have been... more | Michele Malotky |
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| nmr-2 | GRIN2D | This is 2nd of 5 probes found on E-RNAi; chose this one because it had highest percent efficiency and lowest GC content | Kenneth Sossa |
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| alcohol dehydrogenase | alcohol dehydrogenase | ALCOHOL DEHYDROGENASE 1B (ADH1B) is responsible for most of the activity in the adult liver. | Noreen Naiman |
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| xpa-1 | Xeroderma Pigmentosum comp group A | There are 5 exons and 4 introns with a nonexpressed DNA section at the end. | pat lamb |
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| egl-4 | PRKG1 | I am interested in the regulatory pathways affect global organism size. egl-4 deletion or inhibition results in worms that are much larger in size... more | Nicholas Edgington |
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| Xpa-1 | Xeroderma pigmentosum complementation group A | The sequence has 4 introns and 5 exons and an end uncoding region. | Subhas Mukherjee pat lamb |
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| apr-1 | APC Beta-catenin binding protein | required for germline fertility,embyrogenesis, and vulva development | Renee Forde |
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| apr-1 | APC Beta-catenin binding protein | embrogenesis | Ayele gugssa |
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| let-381 | FoxF1 | This gene was the first pick for an ortholog search for human FoxF1 which has been recently implicated to cause Alveolar Capillary Dysplasia. | Partha Sen |
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| cep-1 | p-53 | This gene regulates apoptosis in cells. | Chad Cryer |
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| ceh-45 | Goosecoid | Interested in embryo implantation and read reports on this gene that is hoghly conserved in human, mouse and frogs. | Gloria Regisford |
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| sax-3 | DSCAM | Down syndrome (DS) is a major cause of congenital heart disease (CHD) and the most frequent known cause of atrioventricular septal defects (AVSDs)... more | Veronica Martinez Acosta |
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| egl-19 | voltage-gated sodium channel type V alpha isoform e | The Romano-Ward or Ward-Romano syndrome is a form of heart arrhythmia that shows a long QT syndrome in an EKG. About 1 in 7,000 people have this... more | Donna Janes |
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| hypothetical protein (NP_493545) | hypoxanthine phosphoribosyltransferase 1 | In humans, the protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to... more | A. Tineke Berends |
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| Multiple drug resistance protein family (mrp-1) | cystic fibrosis transmembrane conductance regulator | In volve in multiple drug resistance in C.elegans. | PAUL DRUMMOND |
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| Igc-37 | gamma-aminobutyric acid (GABA) A receptor, alpha 5 precursor | ZC482.5 is orthologous to the human gene GAMMA-AMINOBUTYRIC ACID A RECEPTOR GAMMA 2 (GABRG2; OMIM:137164), which when mutated leads to disease. | Renu Jain |
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| sca-1 | ATP2A2 | The purpose of this project was to induce the gene for a human disease, Darier Disease, in C. elegans by RNAi-induced feeding strain and observe any... more | Sarah Martin |
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| sqv-7 | Squashed vulva | Katelyn Slayter |
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| gap-2 | gap-2 | GTPase Activating Protein family. encodes a Ras GTPase-activating protein essential for postnatal survival and neuronal development. | Julie hinton |
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| tub-1 | FUR1 | This gene involves regulation of fat storage in the head and in the tail region. | Megan Konarik |
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| ifa-1 | Keratin 2 | Ichthyosis bullosa of Siemens (IBS) is an autosomal dominant disorder that affects the skin. Ichthyosis is characterized by the dry and scaly skin... more | Gabriel Castillo |
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| hlh-30 | Mitf | Protein-coding gene that plays the role in development, survival, and function of certain cells; it helps in the function of pigment-producing cells... more | Joseph Cox Ashley Konarik |
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| gap-2 | gap-2 | gap-2 codes for a RAS GTPase Activating Protein and is homologous to the human gene NF1, the mutation of which causes neurofibromatosis. in this... more | Katherine Thompson |
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| col-104 | col17a1 | Genetic disorder affecting collagen. In humans Epidermolysis Bullosa results in severe blistering. | Sara Laroya |
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| gap-2 | NF1, NF2 | gap-2 codes for a RAS GTPase Activating Protein and is homologous to the human gene NF1, the mutation of which causes neurofibromatosis. in this... more | Julie hinton |
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| Mod-1 | Feed DP123 worms a constructed feeding strain containing the PCR product of our primers. Also feed DP123 worms OP50 bacteria. Examined both worms... more | Travis Hardcastle |
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| nhr-49 | hnf4a | Student project. A set of experiments were done to knock down the expression of the gene, nhr-49. The expected phenotypic result was obesity and... more | Bat-Erdene Myagmarjav |
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| fbn-1 | FBN1 | Compared to Wild-type C. elegans worms, the fbn-1 RNAi treated worms were much skinnier and longer. In addition, their head twitched as well. | Kelly Anders |
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| cua-1 | ATP7A | locomotion variant phenotype observed; also body length seemed to be longer than wild-type body length | Keri Kershaw |
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| eff-1 | none | eff-1 is a cell fusion coding gene that when dysfunctional, creates an ectopic phenotype in the worms in which the embryos hatch inside the adults... more | ricardo rivera |
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| DNC-1 | DCTN1 | DNC-1 codes for the protein dynactin which is necessary for motor neuron activity. Without dynactin, microtubules do not function properly resulting... more | Brendan Watson |
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| cdk-1 | cdk-1 | The gene codes for a protein that is vital during cell division. The presence of the protein complex is necessary for mitosis. if there is an error... more | vikram krishnamoorthy |
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| pdr-1 | PARK2 | Although there are multiple genes in humans that cause Parkinson's symptoms, the PARK2 gene (also known as parkin gene) is responsible for causing... more | Kirit Limperis |
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| dys-1 | Dystrophin (DMD) | Duchenne muscular dystrophy results in the progressive weakening of skeletal muscles, defective muscle proteins, and the degeneration of muscular... more | Amanda Lagan JoAnn Tinker |
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| msh-6 | MSH6 | HNPCC, also known as Lynch syndrome, is a disorder that increases the risk of many types of cancer in colon and recum. It may also increase... more | Ximena Capetillo Garcia Williams |
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| gba-3, isoform d | Glucocerebrosidase | GBA-3 is homologous to the human gene, Glucocerebrosidase, a lysosomal enzyme that catalyzes the breakdown of the glycolipid glucosylceramide to... more | Carolyn Blumberg Ayane Rossano |
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| mdf-2 | MAD2L1 | mdf-2 encodes the C. elegans ortholog of the Mad2p spindle assembly checkpoint protein; mdf-2 activity is essential for regulation of the... more | Andrew Kurland |
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| mdf-2 | MAD2L1 | mdf-2 encodes the C. elegans ortholog of the Mad2p spindle assembly checkpoint protein; mdf-2 activity is essential for regulation of the... more | Tom Zhang |
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| let-23 | ERBB2 | Gastric cancer (also known as stomach cancer) is a disease in which the cells that form the inner lining of the stomach become abnormal and begin to... more | Leigh Gulbransen |
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| PRNP *not worm name | PRNP | Humans: Causes neurodegenerative spongiform encephalopathy. Causes uncontrolled movement and emotional problems. Worms: Causes expression in the... more | KKN CDP |
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| Shn-1 | SHANK | In Worms: affects calcium and the verebrea. In Humans: mutations have been found in the autism spectrum diseases. | Catherine Stippell |
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| nhr-99 | HBB | Sickle cell disease describes a group of inherited blood disorders characterized by chronic anemia, painful events, and various complications due to... more | nickicat campellbonacasa |
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| Kars-1 | HLA-DRB1 | Humans: causes muscle weakness and other health problems such as autoimmune disorders, rheumatoid arthritis, and type 1 diabetes Worms:... more | KKN CDP |
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| park-1 | SNCA | the disease genes and disease pathways in humans are conserved in C. elegans, we can tinker with the genes that regulate neuronal cell death in the... more | nickicat campellbonacasa |
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| Y53g8ar.8 | HBB | Human:episodes of acute illness and progressive organ damage. Worms: causes problems with excretory cells; Nervous System; head neurons; pharyngeal... more | KKN CDP |
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| Bcs1l | BCS1L | Leigh syndrome is a severe neurological disorder that typically arises in the first year of life. This condition is characterized by progressive loss... more | nickicat campellbonacasa |
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| R05H5.7 | MVCD1 | In Humans: microvascular complications, retinopathy In Worms: ? | Catherine Stippell |
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| Y48G1C.5 | HNMT | In Humans: affects the bronchi, increased bronchi-constriction In Worms: ? | Catherine Stippell |
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| rs3117582 | we are trying to find signs of a change within the worm that might be linkable to lung Cancer | Tully Frain |
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| DYX1C1 | We wer3 to search for an sign of change in a worm that might make a link to dyslexia | Tully Frain |
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| HMGN1 | we were to look for changes in the worms that could be linked with heart disease in humans. | Tully Frain |
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| EPHB2 | mutation gene which causes prostrate/ brain cancer | Brittany Ford |
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| LMNA | distrupt mitosis and induce dna damage in smooth muscle cells. | Brittany Ford |
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| unc-1 | curled shape, goes in circles | Catherine Stippell |
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| abi-1 | slow, twitching head | Catherine Stippell |
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| pat 11 | trouble wile moving | Catherine Stippell |
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| h14a12.1 | stays mostly straight when moving, dark | Catherine Stippell |
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| misc-1 | spotted | Catherine Stippell |
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| unknown | very very slow moving | Catherine Stippell |
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| h14n18.8 | stays mostly straight when moving, slow | Catherine Stippell |
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| ptr-2 | slow, dark | Catherine Stippell |
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| sco-1 | blister | Catherine Stippell |
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| b0205.4 | thick, dark, large "S" movements | Catherine Stippell |
