Silencing Genomes: Projects

Worm gene Human gene Description Team Media

lin-35 Rb Retinoblastoma occurs in early childhood and affects about 1 child in 20,000. Tumors develop from the immature retina (the part of the eye... more Matthew Allen
Bruce Nash

epi-1 LAMA3 This project is still in progress. Check back for results. Matthew Allen
Joseph Chong
Kay Gamble

K02D7.1 NP Nil Toh Pee Li Leslie

XK675 CBS Homocystinuria is an autosomal recessive disorder of methionine metabolism. Cystathione beta synthase (CBS) is the human gene product that catalyzes... more Philip Jeffery

TEST- 1 sasa some desc goes here sasasa FName LName

rnt-1 RUNX1 The protein encoded by the human gene represents the alpha subunit of Core Binding Factor (CBF) and is thought to be involved in the development of... more Alyson Downing

C31E10.7 CYB5A PCR has been done for the designed primers; no transformation has been done yet. Karen Tiffany

H37A05.1 LPIN-2 (OMIM:605518), LPIN2 (OMIM:605519, mutated in Majeed syndrome), and LPIN3 (OMIM:605520); H37A05.1 is expressed in vulval muscle; in mass RNAi assays... more Kay Gamble

C53D5.5 GGT-1 In humans the enzyme gamma-glutamyl transpeptidase is used in the catabolism of glutathione. It is found on the outer surface of the cell membrane... more Denise Williams

sec-23 SEC23A This gene when repressed by RNAi causes maternal sterility, embryonic lethality, abnormal protein subcellular localization, molting defects, and... more Billie Conway
Randy Dix
Susan Groff
Toh Pee Li Leslie
Lauren Turner
Cathy Williamson

ncr-1 NPC1 Expression of ncr-1 gene is widespread and involves the distribution pattern of cholesterol in various tissues of C. elegans. It was chosen because... more Ada Harvey
Clement Ong
Sanjeed V.K.
Zoe Welsh

K02D10.5 SNAP29 The experiment is incomplete, but at this time, PCR has been done. Ada Harvey
Zoe Welsh

pabp-2 pabpn1 opmd is characterized by late-onset eyelid drooping, difficulty swallowing. as the disease progresses there is tongue atrophy and weakness.In some... more lisa sakol

him-6 BLM Phenotype is developmentally delayed (very extended life cycle time), numerous round rather than ovoid embryos but lack of expected number of larvae... more Denise Williams
Wendy Wooten
lisa sakol

KO2D7.1 NP the gene has been inserted into L4440 and transformed into DH5-alpha E.coli cells. I have also plated this transformed cells for future studies under... more Joseph Chong

C09G5.8 RPGRIP1 None Cathy Williamson

fum-1 Fumarate hydratase Fumarase, or fumarate hydratase (FH), is an enzyme involved in the Krebs cycle, where it catalyzes the formation of L-malate from fumarate. We... more Alyson Downing
Ray Lewis
Karen Tiffany

epi-1 LAMA3 epi-1 encodes an extracellular laminin. We constructed a feeding vector using the noted gene-specific primers and transformed this vector into the... more Susan Groff

Worm gene	Human gene	Description	Team	Media
lin-35	Rb	Retinoblastoma occurs in early childhood and affects about 1 child in 20,000. Tumors develop from the immature retina (the part of the eye... more	Matthew Allen Bruce Nash
epi-1	LAMA3	This project is still in progress. Check back for results.	Matthew Allen Joseph Chong Kay Gamble
K02D7.1	NP	Nil	Toh Pee Li Leslie
XK675	CBS	Homocystinuria is an autosomal recessive disorder of methionine metabolism. Cystathione beta synthase (CBS) is the human gene product that catalyzes... more	Philip Jeffery
TEST- 1	sasa	some desc goes here sasasa	FName LName
rnt-1	RUNX1	The protein encoded by the human gene represents the alpha subunit of Core Binding Factor (CBF) and is thought to be involved in the development of... more	Alyson Downing
C31E10.7	CYB5A	PCR has been done for the designed primers; no transformation has been done yet.	Karen Tiffany
H37A05.1	LPIN-2	(OMIM:605518), LPIN2 (OMIM:605519, mutated in Majeed syndrome), and LPIN3 (OMIM:605520); H37A05.1 is expressed in vulval muscle; in mass RNAi assays... more	Kay Gamble
C53D5.5	GGT-1	In humans the enzyme gamma-glutamyl transpeptidase is used in the catabolism of glutathione. It is found on the outer surface of the cell membrane... more	Denise Williams
sec-23	SEC23A	This gene when repressed by RNAi causes maternal sterility, embryonic lethality, abnormal protein subcellular localization, molting defects, and... more	Billie Conway Randy Dix Susan Groff Toh Pee Li Leslie Lauren Turner Cathy Williamson
ncr-1	NPC1	Expression of ncr-1 gene is widespread and involves the distribution pattern of cholesterol in various tissues of C. elegans. It was chosen because... more	Ada Harvey Clement Ong Sanjeed V.K. Zoe Welsh
K02D10.5	SNAP29	The experiment is incomplete, but at this time, PCR has been done.	Ada Harvey Zoe Welsh
pabp-2	pabpn1	opmd is characterized by late-onset eyelid drooping, difficulty swallowing. as the disease progresses there is tongue atrophy and weakness.In some... more	lisa sakol
him-6	BLM	Phenotype is developmentally delayed (very extended life cycle time), numerous round rather than ovoid embryos but lack of expected number of larvae... more	Denise Williams Wendy Wooten lisa sakol
KO2D7.1	NP	the gene has been inserted into L4440 and transformed into DH5-alpha E.coli cells. I have also plated this transformed cells for future studies under... more	Joseph Chong
C09G5.8	RPGRIP1	None	Cathy Williamson
fum-1	Fumarate hydratase	Fumarase, or fumarate hydratase (FH), is an enzyme involved in the Krebs cycle, where it catalyzes the formation of L-malate from fumarate. We... more	Alyson Downing Ray Lewis Karen Tiffany
epi-1	LAMA3	epi-1 encodes an extracellular laminin. We constructed a feeding vector using the noted gene-specific primers and transformed this vector into the... more	Susan Groff