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Worm gene Human gene Description Team Media
lin-35 Rb Retinoblastoma occurs in early childhood and affects about 1 child in 20,000. Tumors develop from the immature retina (the part of the eye... more
Matthew Allen
epi-1 LAMA3 This project is still in progress. Check back for results. Matthew Allen
Joseph Chong
Kay Gamble
K02D7.1 NP Nil Toh Pee Li Leslie
 
XK675 CBS Homocystinuria is an autosomal recessive disorder of methionine metabolism. Cystathione beta synthase (CBS) is the human gene product that catalyzes... more Philip Jeffery
rnt-1 RUNX1 The protein encoded by the human gene represents the alpha subunit of Core Binding Factor (CBF) and is thought to be involved in the development of... more Alyson Downing
 
C31E10.7 CYB5A PCR has been done for the designed primers; no transformation has been done yet. Karen Tiffany
 
H37A05.1 LPIN-2 (OMIM:605518), LPIN2 (OMIM:605519, mutated in Majeed syndrome), and LPIN3 (OMIM:605520); H37A05.1 is expressed in vulval muscle; in mass RNAi assays... more Kay Gamble
 
C53D5.5 GGT-1 In humans the enzyme gamma-glutamyl transpeptidase is used in the catabolism of glutathione. It is found on the outer surface of the cell membrane... more Denise Williams
 
sec-23 SEC23A This gene when repressed by RNAi causes maternal sterility, embryonic lethality, abnormal protein subcellular localization, molting defects, and... more Billie Conway
Randy Dix
Susan Groff
Toh Pee Li Leslie
Lauren Turner
Cathy Williamson
ncr-1 NPC1 Expression of ncr-1 gene is widespread and involves the distribution pattern of cholesterol in various tissues of C. elegans. It was chosen because... more Ada Harvey
Clement Ong
Sanjeed V.K.
Zoe Welsh
K02D10.5 SNAP29 The experiment is incomplete, but at this time, PCR has been done. Ada Harvey
Zoe Welsh
 
pabp-2 pabpn1 opmd is characterized by late-onset eyelid drooping, difficulty swallowing. as the disease progresses there is tongue atrophy and weakness.In some... more lisa sakol
 
him-6 BLM Phenotype is developmentally delayed (very extended life cycle time), numerous round rather than ovoid embryos but lack of expected number of larvae... more Denise Williams
Wendy Wooten
lisa sakol
KO2D7.1 NP the gene has been inserted into L4440 and transformed into DH5-alpha E.coli cells. I have also plated this transformed cells for future studies under... more Joseph Chong
 
C09G5.8 RPGRIP1 None Cathy Williamson
 
fum-1 Fumarate hydratase Fumarase, or fumarate hydratase (FH), is an enzyme involved in the Krebs cycle, where it catalyzes the formation of L-malate from fumarate. We... more Alyson Downing
Ray Lewis
Karen Tiffany
epi-1 LAMA3 epi-1 encodes an extracellular laminin. We constructed a feeding vector using the noted gene-specific primers and transformed this vector into the... more Susan Groff
 
col-39 ectodysplasin A There are more than 150 clinically distinct hereditary syndromes in which ectodermal dysplasia is present. Most syndromes are very rare and manifest... more robert Ross
ncr1 npc1 Niemann-Pick type C (NPC) disease is an autosomal recessive lipid storage disorder characterized by progressive neurodegeneration. Approximately 95%... more Din-Pow Ma
 
ATM-1 ATM Ataxia T is an autosomal recessive human disease that causes immune defects, predisposition to canacer & supersensitivity to ionizing radiation. AT... more Shahira Badran
 
D2023.5 MPT- mercaptopyruvate sulfur transferase Mercaptopyruvate sulfur transferase transfers sulfur ion from 3' sulfur of mercaptopyruvate to a variety of acceptors. Physiological acceptor is... more David Wing
 
hex-1 HEXA Tay-Sachs disease is a rare inherited disorder that causes progressive destruction of nerve cells in the brain and spinal cord. More than 100... more Susan Gingold
 
egl-15 FGRF3 Achondroplasia is an autosomal dominant disorder characterized by abnormal bone growth that results in short stature with disproportionately short... more Kevin Hansen
 
ubc-20 huntingtin Huntington's disease is an autosomal dominant disorder that typically appears beginning in mid-life. An ortholog in C. elegans to one of the genes... more
Meg Rawls
 
B0432.4 UPC2 The uncoupling protein plays a role in producing heat and burning calories by creating trails that allows dissipation of the proton electrochemical... more Lender Luse
 
nob-1 NOB1 nob-1 encodes a HOX protein, in the posterior paralog group in C. elegans. In yeast, nob-1 is required for proteasome function and RNA metabolism. Sandra Thompson-Jaeger
 
hmr-1 Cadherin 1 Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are... more robert Ross
cft-1 cft-1 Related to the gene that produces a transmembrane protein responsible for moving chloride across the cell membrane. Lynda Miller
 
ctb-1 mitochondrial cytochrome b There is some evidence to indicate that a defect in the gene encoding the mitochondrial electron transport protein, cytoshrome Ib, is involved in... more mary ogilvie
 
XPA-1 XPA Human gene XPA is one of the genes that when muatated cauases the disease Xeroderma Pigmentosum. This condition is charactierized by extreme... more Jim Youngblom
 
ape-1 p53 ape-1 refers to an apoptosis enhancer gene first discovered by Kuwabara. It encodes a 769 aa protein that induces apoptosis in the germline and... more Tucker Crum
 
pmp-4   Right primer starts at 1121 and left primer starts at 1495. Both primers are 20 bases each. Dr. Chandramouly Tummalapalli
 
brc-1 BRCA1 brc-1 in C. elegan is closely related to BRCA1 in humans. BRCA1 causes an early onset breast and ovarian cancer. BRC-1 damage chromatin... more Lender Luse
 
unc-26 GBA2 Acid beta-glucocerebrosidase, also known as beta-glucosidase (GBA; EC 3.2.1.45), is a lysosomal enzyme that catalyzes the breakdown of the glycolipid... more Din-Pow Ma
 
DJ-1 PARK7 Parkinson's disease is a movement disorder characterized by loss of dopaminergic neurons. DJ-1 interacts with p53 in vivo and in vitro; it... more Sandra Thompson-Jaeger
 
cep-1 TRP 53 Right primer starts at 4044 and left primer starts at 4436. Dr. Chandramouly Tummalapalli
 
fasn-1 p63 This gene encodes a fatty acid synthase like human FASN (Omim:600212) and the protein might be a direct target of p53-like proteins. Tucker Crum
 
Y50D7A.10 GMF-B Glial maturation factor beta was first linked to differentiation of brain cells, and later shown to aid neural regeneration and limit proliferation... more kevin lyon
 
fbl-1 fibrillin-1 Marfan syndrome is a connective-tissue disorder inherited as an autosomal dominant trait. Approximately 25% of cases are caused by a spontaneous... more Kevin Hansen
 
APL-1 APP (amyloid beta A4 precursor protein) Twisted plaques are visible in the brains of people with Alzheimer's disease. This human gene produces the precursor protein that is found in the... more Jim Youngblom
 
F07h5.2 SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotei right primer start at 2 left primer start at 553 mehdi moghbel
 
T07D3.4 fukutin right primer start at 1608 left primer start 2342 mehdi moghbel
 
sir-2.1 SIRT1 In the news recently is hype about red wine as the new fountain of youth because of a human homolog of the worm and yeast protein product of this... more Tucker Crum
 
nlg-1 neuroligin-3 Autism spectrum disorder is a developmental disorder characterized by impaired social interactions & communication skills along with repetitive... more Lisa German
 
pat-2 Platelet Glycoprotein IIb Glanzman's thrombasthenia is characterized by increased clotting time due to a mutation in the GPIIb gene. Glycoprotein IIb and Glycoprotein IIa... more mary ogilvie
 
lin-35 (abnormal cell LINeage family member) Retinoblastoma 1 This genetic disease affects the eyesight of young children particularly below the age of 5. Cancerous cells originating from the eyes spread fast to... more Ee Ling Tan
 
C18H7   von Willebrand factor and related coagulation proteins. A hemorrhagic condition in persons living on the Aland Islands in the Sea of Bothnia between... more Jeanelle Hardwick
 
hex-1 N-acetyl-beta-glucosaminidase prepro-polypeptide Tay sachs disease TSD is inherited in an autosomal recessive pattern. The disease occurs when harmful quantities of a fatty acid derivative called a... more susan schylander
 
ptl-1 microtubule-associated protein tau isoform 5 (MAPT) Wszolek et al. (1992) reported a large kindred in which 32 members in 8 generations had a neurodegenerative disorder characterized by progressive... more Jordan Wolf
 
ets-5- (ETS class transcription factor) ets variant gene 1 In humans, the mutation in the ets variant gene 1 causes the emergence of the disease Prostate Cancer that occurs in males with prevalent occurrence... more Azahar Dahlan
 
W03D8.8 NP_689544 Alzheimer's disease is a progressive, degenerative disease of the brain in which brain cells die and are not replaced. It results in impaired memory... more Renee Leong
 
lgc-37 NP_775807 Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or... more kelly lewis
 
unc-26 19q13.1, 7q31.2 This is a gene involved in transporting chloride ions across cell membranes.Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a... more Tom Freeman
 
gtl-2 15q21 "Amyotrophic lateral sclerosis-parkinsonsim/dementia complex of Guam is a neurodengenerative disorder with unusually high incidence among the... more Brenda Royal
 
dcr-1 Dicer 1 What happens if an extra copy of dicer is added to the genome? Does the silencer get silenced? Jaak Raudsepp
 
gene name N/A K07A12.2 locus = NP_492348 P98161.2 In humans: A number sign (#) is used with this entry because of evidence that polycystic kidney disease (PKD) may arise from mutations in any of... more Sondra Stark
 
N/A ARMD4 (AGE-RELATED MACULAR DEGENERATION); COMPLEMENT FACTOR H ARMD4: there is a significant association between ***polymorphism in the gene encoding complement factor H (CFH; 134370) and susceptibility to... more David Barry
 
Hex-1 NP_000511.2 hexosaminidase A Tay-Sachs is caused by the absence of the enzyme hexosaminidase-A (Hex-A). Without Hex-A, a lipid, called GM2 accumulates in cells, especially in the... more lutz holzinger
 
Collagen WormBase:WBGene00004300 NP_536348 #266600 INFLAMMATORY BOWEL DISEASE 1; IBD1 REGIONAL ENTERITIS CROHN DISEASE Inflammatory bowel disease is characterized by a chronic relapsing... more Sherry Davis
 
Y11B2A.8 PRKAG2;062743 WPW can be caused by a mutation in the gamma-2 regulatory subunit of AMP-activated protein kinase. Features: short PR interval and prolonged QRS on... more Nancy Wyllie
 
OSM-3 KIF17 This is all the information I could find at this time. Ernest Archer
 
pdr-1 (Parkinson's Disease Related) human parkin (PARK2) Parkinson's disease is a degenerating disease that affects the central nervous system. People affected by this disorder suffer from degeneration of... more Azahar Dahlan
Renee Leong
Ee Ling Tan
 
Col-135 Col29A1 Atopic Dermatitis or eczema is an inflammatory disease that begins early in life. Symptoms of eczema include inflammation in the epidermal layer of... more Donna Drontle
 
abl-1 abl-1 ABL-1 inhibits germline apoptosis induced by radiation or by natural aging, but it has no effect on apoptosis induced by starvation or by chemical... more Jordan Wolf
 
Lrk-1 LRRK-2 (PARK 8) LRRK2 is a gene identified in familial forms of Parkinson's disease (PD)and may be central to the pathogenesis of several major neurodegenerative... more Kathryn Kehoe
 
dys-1   Dystrophin-associated muscular dystrophies range from the severe Duchenne muscular dystrophy (DMD) to the milder Becker muscular dystrophy (BMD... more Carol Keyes
 
spe-15 MYO6 The spe-15 gene encodes an unconventional myosin that is homologous to both Drosophila and mouse myosin VI; it also has homologues in many other... more Brenda Leicht
 
lmn-1 lamin A LMN-1 encodes the sole C. elegans nuclear lamin; LMN-1 protein is essential for the nuclear envelope localization of emerin (EMR-1) protein during... more Karen Dalfrey
 
daf-2 Insulin receptor C. elegans with defective daf-2 correspond to insulin resistance and Type II diabetes. Georgia Hammond
 
unc-32 ATP6V0A2 primers from e-rnai for this vacuolar ATPase gene subunit a2 The protein that it codes for moves from inside the cell to the surface of a subset... more Kristy Shanahan
 
Y42G9A.4 Mevalonate kinase This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid... more Debra Hinson
 
msh-2 msh-2 Cololrectal cancer is a major health issue. Several genes have been shown to be associated with hereditary non-polyposis colon cancer, including... more Elizabeth Critser
 
ugt-62 UDP glucuronosyltransferase 1 family, polypeptide A1 The human ortholog of the C. elegans ugt-62 gene is associated with an autosomal recessive genetic disorder in which bilirubin cannot be conjugated... more Kevin Stilwell
 
tag-144 HPC1 Prostate cancer is a common pathology of human males and is beginning to be understood on the genetic level. The worm ortholog of the human HPC1... more William Yamokoski
 
dpy-17 NP_00384 In humans, Ehlers-Danlos (E.D.) syndrome is a disorder affecting collagen V and produces symptoms in patients including looseness of joints, easily... more Sandra Davis
Mary Ritke
 
T13C2.6 VLDL receptor (very low density lipoprotein receptor) Unertan syndrome has been discovered in a family in Turkey. Members of this family walk on all four limbs. The mutation maps to the VLDL receptor... more Lark Claassen
 
mrp-6 CFTR Source: OMIM Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a chloride channel and controls the regulation of other... more Donna-Marie Gardner
 
vha-6 VPP1 (OMIM:192130) vha-6 (vacuolar H ATPase) is orthologous to the VPP1 gene in humans. The VPP1 gene in humans causes distal renal tubular acidosis and osteopetrosis. Nickie Cauthen
 
mec-5 alpha 2 type V collagen preproprotein In humans, Ehlers-Danlos (E.D.) syndrome is a disorder attributed to mutations collagen V. Most persons with the Ehlers-Danlos syndrome are born... more Sandra Davis
Mary Ritke
 
ttx-1 Otx2 In progress. James Smith
 
apr-1 APC Source: OMIM. "The APC gene encodes a multidomain protein that plays a major role in tumor suppression by antagonizing the WNT signaling pathway... more Lark Claassen
 
dys-1 DMD Duchenne Muscular Dystrophy is an X-linked disorder that causes progressive muscle degeneration. Onset of symptoms occurs between 2-5 years of age... more Janet Baker
 
dys-1 DMD The dys-1 gene encodes an ortholog of human DMD, which when mutated leads to Duchenne muscular dystrophy (OMIM:310200)or to the milder form Becker... more
Rebecca Ross
 
F29B9.4 c-fos The AP-1 transcription factor is composed of members of the Fos and Jun DNA binding proteins families. AP-1 is involved in response to several... more Deborly Wade
 
PAH-1 phenylalanine hydroxylase Phenylketonuria (PKU) is an autosomal recessive inborn error of metabolism resulting from a deficiency of phenylalanine hydroxylase (EC 1.14.16.1)... more Maggie Boylan
 
hum-6 MYO7A and MYO15A hum-6 is orthologous to the human gene MYOSIN VIIA (MYO7A; OMIM:276903), which when mutated leads to Usher syndrome type IB. hum-6 is also... more Shelley Acosta
 
olrn-1 na Homolog of a Drosophila gene. Katherine Bates
 
pdi-2 na Protein disulfide isomerase Katherine Bates
 
Caenorhabditis elegans -dys 1 dys 1 The dys-1 gene encodes an ortholog of human DMD, which when mutated leads to Duchenne muscular dystrophy
Vimlarani Chopra
 
lbp-5 DHTR (dihydrotestosteron receptor) Androgen insensitivity syndrome is a condition that affects sexual development before birth and during puberty. People with this condition are... more
Sanghamitra Mohanty
 
F15D3.1a DMD (dys-1) Duchenne Muscular Dystrophy is an X-linked disorder that causes progressive muscle degeneration. Onset of symptoms occurs between 2-5 years of age... more Vimlarani Chopra
 
tsp-8 Kangai-1; KAI-1 tsp-8 is an orthologue to the human metastasis suppressor gene, Kangai-1, or KAI-1. The gene is a member of the tetraspanin superfamily of genes... more Kevin Toal
 
sma-2 SMAD1 SMAD1, the human homolog of the Drosophila gene MAD1 (Mothers Against Decapentaplegic 1), encodes a protein involved in the BMP (bone morphogenic... more Janice Lai
 
Col-135 collagen type XXIX alpha 1 Atopic dermatitis (eczema) exhibits a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry... more Elizabeth Ramirez Garza
 
let-60 Ras Ras is a family of proteins involved in cell signaling pathways that modulate cell growth and proliferation. Mutations in the Ras family(H-Ras... more Angela Wheeler
 
cua-1 ATP7A Menkes disease is an X-linked recessive mutation in a gene coding for a Cu(2+)-transporting ATPase. It results in copper deficiency which causes... more
Virginia Balke
 
pxl-1 paxillin Neurofibromatosis type II is an autosomal dominant disorder (cancer) that results in tumors (schwannomas) in the nervous system. Loss of NF2 has... more Kristen Johnson
 
Lam1 lamin gene Lam 1 encodes nuclear lamin in C. elegans. This protein is required for nuclear envelope localization during early development since the protein... more M. Elaine Cox
 
Transketolase BCKDHA Maple syrup urine disease (MSUD) is an autosomal recessive disorder that is most prevalent among some Mennonite populations. There are several... more Chris Barton
 
SRC-1 Her2/neu aka ERBB2 HER2/neu aka ERBB2, Human Epidermal Growth Factor receptor 2, is a protein that gives higher aggressiveness in breast cancer. Y92H12A.1 is the C... more Judith Coston
 
clh-3 CLC-2 The worm gene clh-1 codes for a chloride channel. It is homologous to the human channel CLC-2. The CLC class of chloride channels/transporters are... more Dan Hansen
 
stn-2 syntrophin Iin C. elegans, this protein is associated with neurons and muscles, and is known to cause abnormal locomotion and head movements Ray Hong
 
ptl-1 tau/MAP2/MAP4 microtubule binding protein homologous to tau/MAP2/MAP4 associated with neurodegenerative disorders including Alzheimers and Picks Disease Hope Johnson
 
C46E1.3 none unknown gene with no known human homolog and known C. elegans RNAi or mutant phenotype Ray Hong
 
Let-29 Protein Phosphatase 2A PP2A is a ubiquitious protein phosphatase involved in a number of cellular processes. We are interested in its interaction with the cyanobacterial... more Aparna Sreenivasan
 
kpc-1 Furin Kex-2/furin like serine protease; other furin-like convertases are implicated in Notch and TGF-beta signaling pathways. Alison Miyamoto
 
dpy-28 CNAP1 This protein is involved in negative chromosome-wide regulation of X chromosome gene expression and is known to cause abnormalities in embryogenesis... more Ray Hong
 
sel-12 presenelin (PS1) transmembrane protein orthologous to presenilins, regulation of notch-like signaling pathways Hope Johnson
 
K10D6.4 none This gene has no homologs outside of nematodes and encodes for proteins with unknown function. There is no reported RNAi or mutant phenotype Ray Hong
 
ptp-2 PTPN11 Explore the effects of silencing this gene in c.elegans. The human disease is characterized by multiple lentigines, electrocardiographic conduction... more Richard Johnston
 
SIMILAR TO XERODEMA PIGMENTOSUM D XPD mutation leads to pre-natal developmental problems such as"larval arrest", "embryonic lethal", and post-natal problems such as "slow growth" and... more Crima Pogge
 
Leptin receptor gene-related protein Ob-RGRP Obesity is a major epidemic disease today. Genetic studies in mice models have revealed the leptin signaling pathway as a regulator of body weight... more Nitika Parmar
 
erm-1 villin 2 (ezrin) The ezrin protein encoded by the human villin-2 gene plays a role in signal transduction, cell motility, migration and metastasis. Ezrin is... more Melissa Rowland-Goldsmith
 
Peroxisome Proliferator-Activated Receptor gamma Peroxisome Proliferator-Activated Receptor gamma Key nuclear transcription factor that determines cell adipogenic differentiation and cell proiferation
Virender Rehan
 
gspd-1 G6PD G6PD deficiency is a common metabolic disease with multiple genetic lesions leading to a range of clinical manifestations from anemia to hemolytic... more Buran Haidar
 
FRM-1 TERT erythrocyte membrane protein. Ortholog to hTERT gene for telomerase catalization. Derrick Lavoie
 
C05H8.1a Calcium/calmodulin dependent protein kinase kinase 2 protein iso Calcium/calmodulin dependent protein kinases play important role in calcium-mediated signal transduction pathway. One example of this is unc-43 in C... more Sagarika Dash
 
GFP within the GFP-marked C. elegans strain AZ235 None The project aims at silencing GFP expression in AZ235 using RNAi for visual assessment under UV microscope. Buran Haidar
 
apl-1 APLP1 This gene encodes an almost identical isoform orthologous to human APLP-1, the overexpression of which may cause abnormal locomotion, infertility... more Xin Wen
 
Prdx-2 peroxiredoxin explore the effect of silencing Prdx-2 on worms and its role in antioxidant defence against envionmental radiation. tieli wang
 
kin-2 cAMP_dependent protein kinase homolog of cAMP_dependent protein kinase specificity 51.34 efficiency 7 primer set #2 to silence single kinases that modify tyrosine hydroxylase... more Susan Colette Daubner
 
fcd-2 Fanconi anemia complementation group D2 isoform b (homo sapiens) cd-2 encodes an ortholog of the human gene FANCD2 (mutated in Fanconi anemia, OMIM:227646) that is strongly required for resistance to DNA... more Wendy Jamison
 
ftt-2 14-3-3 proteins: beta, delta, gamma, eta, zeta, tau, epsilon probe specificity 51.39 efficiency 17.93 primer ranking 1 in vertebrates there are 7 isoforms of 14-3-3 protein, so there mayl be several targets... more Susan Colette Daubner
 
pat-2 integrin alpha subunit In C. elegans, pat-2 encodes alpha integrin subunit. This gene is essential for body wall assembly and function, hence proper development and... more Susan Mechanic-Meyers
 
C06H2.3 HIF-1a (603348) Interested in HIF (Hypoxia Induced Factor)-1 in humans that has been associated with Diebetes and other human diseases. It is a transcription factor... more Ron Kaltreider
 
cmd-1 calmodulin efficiency 41.24 primer ranking 2 to silence proteins that affect the activity of tyrosine hydroxylase TyrH. calmodulin-calcium kinase labels TyrH... more Susan Colette Daubner
 
cmk-1 calmodulin calcium dependent protein kinase probe specificity 100.00 efficiency 29.11 primer ranking 1 to silence proteins that affect the activity of tyrosine hydroxylase TyrH... more Susan Colette Daubner
 
F36H5.4 dystrophin muscular dystrophy is a genetic disease resulting from a deletion in group of genes associated with the production of normal muscle protein named... more mohammed abbas
 
let-23 EGF-R The EGF-R initiates many pathways within the cell including the Ras-Raf-MEK-ERK signaling system. Abnormal regulation of the pathway is known to... more Steven Theroux
 
mek-2 ERK kinase, MEK kinase efficiency 40.23 primer ranking 1 to silence single kinases that modify tyrosine hydroxylase to see how important phosphorylation is in vivo (C... more Susan Colette Daubner
 
WBGene00001442 Fox03A Forkhead transcription factors are associated with G2-M checkpoint regulations. In addition, higher levels of FOXO3A have been assoicated with... more Ron Kaltreider
 
hypothetical gene Aryl-hydrocarbon receptor-interacting protein This gene is associated with the vertebrate retina. However, C. elegans does not appear to have an homologous sensory structure. Judith Ogilvie
 
rskn-1 RPS6KA3 rskn-1 is a member of a multigene family that includes growth factor-regulated serine/threonine kinases. The human homologue RPS6KA3 is involved in... more Lucia Vazquez
 
Ceh-10 vsx1 This is a homeobox gene important for development of head and retina. Judith Ogilvie
 
ags-3 pcp2 This gene is associated with neurons in the retina and cerebellum of vertebrates. Judith Ogilvie
 
yop-1 dp1l1 this gene is highly conserved from yeast to human and is associated with vesicular transport. Judith Ogilvie
 
R02F2.8 AUX1 (Arabidopsis thaliana) plant gene on chromosome 2 amino acid transmembrane transporter Kelly Barry
 
emb-9 Collagen, type II, Alpha -1 emb-9 encodes the alpha-1 chain of Type IV basement membrane collagen most closely equivalent to human COL4A1 (OMIM:120130) on the basis of... more Margaret Bahe
 
lin-1 ETS transcription factor Lin-1 encodes a member of the highly conserved ETS transcription factor family. In C.elegans, LIN-1 is a negative regulator of vulval development... more Patti Erickson
 
ftn-2 FTH1 Hemochromatosis is called “iron overload disease” and is a highly underdiagnosed condition in that damage occurs years before any symptoms are... more Deborah Taylor
 
CCO-1 COX5B COX is involved in the electron transport chain and is associated with multiple human diseases. Ron Kaltreider
 
APC-1 APC Many colorectal cancers are caused by the autosomal dominant gene, adenomatous polyposis coli. This gene interferes with the Wnt signaling pathway in... more Rosemary Ford
 
Sod-1 Sod-1 A mutation in the S0D-1 in humans is associated with ALS. The mutation in the gene in the C. elegans worm is associated with a phenotypic expression... more Alisa Petree
 
F13B12.5 Insulin Insulin is required to bind to a cell surface receptor before glucose can enter the cells. Impaired or lack of insulin production results in type I... more Ron McNeel
 
daf-7 TGFB-1 This human gene has been shown to be associated with the production of keloid. I would like to see the phenotype in worms when this gene is knocked... more Jocelyn Ramos
 
unc-2 CACNA1A Mutations in this gene produce a defective alpha 1A subunit of the voltage-dependent calcium channel. Human mutations affect the nervous system... more Elisabeth Kasckow
 
dop-4 DRD4 A mutation in this gene produces a defective dopamine D2-like receptor that inhibits adenylyl cyclase. Human mutations are associated with attention... more Elisabeth Kasckow
 
ver-4 VEGF In humans, VEGF is a protein crucial to endothelial cell growth. When mutated, endothelial cells do not replicate sufficiently to keep blood vessels... more Allison B. Jablonski
mrp-1 CF Transmembrane Conductance Regulator: ABC superfamily protien mrp-1 encodes an ATP-binding cassette (ABC) transporter most closely related to the multidrug resistance-associated proteins; mrp-1 activity is... more Joshua Stuart
 
rnf-113 Breast cancer 1 gene early onset isoform 5 Human breast cancer 1 gene early onset isoform 5 blasted against C elegans database. RiNg finger protein family member was homologous based on a... more Teresa Singleton
 
skn-1 Nrf2 NRF2 has a hydrophilic N-terminal domain, followed by an acidic region with characteristics of a DNA activation domain, a central cnc homology region... more Vanessa Fitsanakis
PVF-1 platelet-derived growth factor alpha isoform 2 preproprotein [Ho In a study of chemokine expression in fibroblasts from patients with systemic sclerosis and controls, Galindo et al. (2001) found that systemic... more Anastasia Smith
 
Tyramine Beta Hydroxylase family member tbh-1 Dopamine beta-hydroxylase catalyzes the oxidative hydroxylation of dopamine to norepinephrine Susan Lentz
 
F53F4.10 (Hypothetical protein) NADH-Ubiquinone Oxidoreductase Flavoprotein 2; NDUFV2 Within the CNS, mitochondrial complex I deficiency appears to be confined to the substantia nigra. Evidence implicates the 24-kD subunit of... more Vanessa Fitsanakis
RIC-3 hric3 Ric-3 encodes novel highly charged protein with two transmembrane domains and extensive coiled-coil domains; Ric-3 necessary for maturation and... more Betty Davidson
 
egl-15 FGFR-1 Fibroblast growth factor receptor 1 (FGFR-1) is a tyrosine kinase regulating cell division. In some families, a mutation in FGFR-1 results in... more Allison B. Jablonski
 
rep-1 rep-1 Choroideremia (CHM) is an X-linked,recessive, degenerative disorder of the choroid and retina of the human eye. The known defect in most CHM cases is... more Frances Weaver
 
sli-1 CBL C. elegans has one ErbB gene, called let-23, which controls the amount of vulval tissue in these animals. In an analogous manner to the situation in... more Sharla Martin
 
let-60 LOCUS AK292510 1418 bp De novo designed RNAi primer using e-RNAi. This project deals with Pancreatic Acinar Carcinoma (OMIM 260350) Point mutations in codon 12 of the... more Jorge Vasquez-Kool
 
cua-1 ATP7A My best friend had to have a liver transplant due to a copper transport disease (Wilsons disease) and this gene was closely related in C. elegans Richard Vestal
 
smf-3 NRAMP1 Score = 535 bits (1377), Expect = 2e-151, Identities = 286/553 (51%), Positives = 371/553 (67%), Gaps = 24/553 (4%) Hamid Mukhtar
 
ace-1 NLGN3 (Neuroligin-3) Asperger's syndrome is a mild variant of autism spectrum disorder. A number of possible gene candidates for familial forms of the disorder have been... more Michele Malotky
 
nmr-2 GRIN2D This is 2nd of 5 probes found on E-RNAi; chose this one because it had highest percent efficiency and lowest GC content Kenneth Sossa
 
alcohol dehydrogenase alcohol dehydrogenase ALCOHOL DEHYDROGENASE 1B (ADH1B) is responsible for most of the activity in the adult liver. Noreen Naiman
 
xpa-1 Xeroderma Pigmentosum comp group A There are 5 exons and 4 introns with a nonexpressed DNA section at the end. pat lamb
 
egl-4 PRKG1 I am interested in the regulatory pathways affect global organism size. egl-4 deletion or inhibition results in worms that are much larger in size... more Nicholas Edgington
 
Xpa-1 Xeroderma pigmentosum complementation group A The sequence has 4 introns and 5 exons and an end uncoding region. Subhas Mukherjee
pat lamb
 
apr-1 APC Beta-catenin binding protein required for germline fertility,embyrogenesis, and vulva development Renee Forde
 
apr-1 APC Beta-catenin binding protein embrogenesis Ayele gugssa
 
let-381 FoxF1 This gene was the first pick for an ortholog search for human FoxF1 which has been recently implicated to cause Alveolar Capillary Dysplasia. Partha Sen
 
cep-1 p-53 This gene regulates apoptosis in cells. Chad Cryer
 
ceh-45 Goosecoid Interested in embryo implantation and read reports on this gene that is hoghly conserved in human, mouse and frogs. Gloria Regisford
 
sax-3 DSCAM Down syndrome (DS) is a major cause of congenital heart disease (CHD) and the most frequent known cause of atrioventricular septal defects (AVSDs)... more Veronica Martinez Acosta
 
egl-19 voltage-gated sodium channel type V alpha isoform e The Romano-Ward or Ward-Romano syndrome is a form of heart arrhythmia that shows a long QT syndrome in an EKG. About 1 in 7,000 people have this... more Donna Janes
 
hypothetical protein (NP_493545) hypoxanthine phosphoribosyltransferase 1 In humans, the protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to... more A. Tineke Berends
 
Multiple drug resistance protein family (mrp-1) cystic fibrosis transmembrane conductance regulator In volve in multiple drug resistance in C.elegans. PAUL DRUMMOND
 
Igc-37 gamma-aminobutyric acid (GABA) A receptor, alpha 5 precursor ZC482.5 is orthologous to the human gene GAMMA-AMINOBUTYRIC ACID A RECEPTOR GAMMA 2 (GABRG2; OMIM:137164), which when mutated leads to disease. Renu Jain
 
sca-1 ATP2A2 The purpose of this project was to induce the gene for a human disease, Darier Disease, in C. elegans by RNAi-induced feeding strain and observe any... more Sarah Martin
 
sqv-7   Squashed vulva Katelyn Slayter
 
gap-2 gap-2 GTPase Activating Protein family. encodes a Ras GTPase-activating protein essential for postnatal survival and neuronal development. Julie hinton
 
tub-1 FUR1 This gene involves regulation of fat storage in the head and in the tail region. Megan Konarik
 
ifa-1 Keratin 2 Ichthyosis bullosa of Siemens (IBS) is an autosomal dominant disorder that affects the skin. Ichthyosis is characterized by the dry and scaly skin... more Gabriel Castillo
 
hlh-30 Mitf Protein-coding gene that plays the role in development, survival, and function of certain cells; it helps in the function of pigment-producing cells... more Joseph Cox
Ashley Konarik
 
gap-2 gap-2 gap-2 codes for a RAS GTPase Activating Protein and is homologous to the human gene NF1, the mutation of which causes neurofibromatosis. in this... more Katherine Thompson
 
col-104 col17a1 Genetic disorder affecting collagen. In humans Epidermolysis Bullosa results in severe blistering. Sara Laroya
gap-2 NF1, NF2 gap-2 codes for a RAS GTPase Activating Protein and is homologous to the human gene NF1, the mutation of which causes neurofibromatosis. in this... more Julie hinton
 
Mod-1   Feed DP123 worms a constructed feeding strain containing the PCR product of our primers. Also feed DP123 worms OP50 bacteria. Examined both worms... more Travis Hardcastle
 
nhr-49 hnf4a Student project. A set of experiments were done to knock down the expression of the gene, nhr-49. The expected phenotypic result was obesity and... more Bat-Erdene Myagmarjav
 
fbn-1 FBN1 Compared to Wild-type C. elegans worms, the fbn-1 RNAi treated worms were much skinnier and longer. In addition, their head twitched as well. Kelly Anders
 
cua-1 ATP7A locomotion variant phenotype observed; also body length seemed to be longer than wild-type body length Keri Kershaw
 
eff-1 none eff-1 is a cell fusion coding gene that when dysfunctional, creates an ectopic phenotype in the worms in which the embryos hatch inside the adults... more ricardo rivera
DNC-1 DCTN1 DNC-1 codes for the protein dynactin which is necessary for motor neuron activity. Without dynactin, microtubules do not function properly resulting... more Brendan Watson
 
cdk-1 cdk-1 The gene codes for a protein that is vital during cell division. The presence of the protein complex is necessary for mitosis. if there is an error... more vikram krishnamoorthy
 
pdr-1 PARK2 Although there are multiple genes in humans that cause Parkinson's symptoms, the PARK2 gene (also known as parkin gene) is responsible for causing... more Kirit Limperis
 
dys-1 Dystrophin (DMD) Duchenne muscular dystrophy results in the progressive weakening of skeletal muscles, defective muscle proteins, and the degeneration of muscular... more Amanda Lagan
JoAnn Tinker
 
msh-6 MSH6 HNPCC, also known as Lynch syndrome, is a disorder that increases the risk of many types of cancer in colon and recum. It may also increase... more Ximena Capetillo Garcia Williams
 
gba-3, isoform d Glucocerebrosidase GBA-3 is homologous to the human gene, Glucocerebrosidase, a lysosomal enzyme that catalyzes the breakdown of the glycolipid glucosylceramide to... more Carolyn Blumberg
Ayane Rossano
 
mdf-2 MAD2L1 mdf-2 encodes the C. elegans ortholog of the Mad2p spindle assembly checkpoint protein; mdf-2 activity is essential for regulation of the... more Andrew Kurland
 
mdf-2 MAD2L1 mdf-2 encodes the C. elegans ortholog of the Mad2p spindle assembly checkpoint protein; mdf-2 activity is essential for regulation of the... more Tom Zhang
 
let-23 ERBB2 Gastric cancer (also known as stomach cancer) is a disease in which the cells that form the inner lining of the stomach become abnormal and begin to... more Leigh Gulbransen
 
PRNP *not worm name PRNP Humans: Causes neurodegenerative spongiform encephalopathy. Causes uncontrolled movement and emotional problems. Worms: Causes expression in the... more KKN CDP
 
Shn-1 SHANK In Worms: affects calcium and the verebrea. In Humans: mutations have been found in the autism spectrum diseases. Catherine Stippell
 
nhr-99 HBB Sickle cell disease describes a group of inherited blood disorders characterized by chronic anemia, painful events, and various complications due to... more nickicat campellbonacasa
 
Kars-1 HLA-DRB1 Humans: causes muscle weakness and other health problems such as autoimmune disorders, rheumatoid arthritis, and type 1 diabetes Worms:... more KKN CDP
 
park-1 SNCA the disease genes and disease pathways in humans are conserved in C. elegans, we can tinker with the genes that regulate neuronal cell death in the... more nickicat campellbonacasa
 
Y53g8ar.8 HBB Human:episodes of acute illness and progressive organ damage. Worms: causes problems with excretory cells; Nervous System; head neurons; pharyngeal... more KKN CDP
 
Bcs1l BCS1L Leigh syndrome is a severe neurological disorder that typically arises in the first year of life. This condition is characterized by progressive loss... more nickicat campellbonacasa
 
R05H5.7 MVCD1 In Humans: microvascular complications, retinopathy In Worms: ? Catherine Stippell
 
Y48G1C.5 HNMT In Humans: affects the bronchi, increased bronchi-constriction In Worms: ? Catherine Stippell
 
rs3117582   we are trying to find signs of a change within the worm that might be linkable to lung Cancer Tully Frain
 
DYX1C1   We wer3 to search for an sign of change in a worm that might make a link to dyslexia Tully Frain
 
HMGN1   we were to look for changes in the worms that could be linked with heart disease in humans. Tully Frain
 
EPHB2   mutation gene which causes prostrate/ brain cancer Brittany Ford
 
LMNA   distrupt mitosis and induce dna damage in smooth muscle cells. Brittany Ford
 
unc-1   curled shape, goes in circles Catherine Stippell
 
abi-1   slow, twitching head Catherine Stippell
 
pat 11   trouble wile moving Catherine Stippell
 
h14a12.1   stays mostly straight when moving, dark Catherine Stippell
 
misc-1   spotted Catherine Stippell
 
unknown   very very slow moving Catherine Stippell
 
h14n18.8   stays mostly straight when moving, slow Catherine Stippell
 
ptr-2   slow, dark Catherine Stippell
 
sco-1   blister Catherine Stippell
 
b0205.4   thick, dark, large "S" movements Catherine Stippell