Worm gene name:  pat-2
Worm sequence name:  F54F2.1
Related human gene:  integrin alpha subunit
Associated human disease:  skin cancer/psoriasis
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Left primer sequence:  gctccagcttgttctccaac
Right primer sequence:  ggaaaatgatggccagaaga
Size of PCR product:  435
Brief description:  In C. elegans, pat-2 encodes alpha integrin subunit. This gene is essential for body wall assembly and function, hence proper development and hatching.
Integrins belong to a family of cell-extracelluar matrix adhesion molecules. It has been seen that some human basal cell carcinomas and other skin diseases reveal altered/upregulated integrin expression. Thus, integrins, (specifically alpha subunit components) and their receptors may participate in modulation of growth, development, and organization of human skin, and may present potential targets for anti-tumor therapy.
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