| Worm gene name: | skn-1 |
| Worm sequence name: | T19E7.2 |
| Related human gene: | Nrf2 |
| Associated human disease: | Thought to be a new treatment target for PD and other diseases related to increased oxidative stress |
| People involved in this project: |
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| Left primer sequence: | gagaaatcgacagtagcgcc |
| Right primer sequence: | catctcttgcatctcggtca |
| Size of PCR product: | 36 |
| Brief description: | NRF2 has a hydrophilic N-terminal domain, followed by an acidic region with characteristics of a DNA activation domain, a central cnc homology region conserved among NFE2 family members, a basic DNA-binding domain, and a C-terminal leucine zipper dimerization domain that contains charged residues predicted to impede homodimer formation. Data from mammals generated by various groups indicate that Nrf2 induces the expression of a group of cytoprotective, antixenobiotic and antioxidant enzymes that include heme oxygenase-1, NAD(P)H:quinone oxidoreductase and enzymes of glutathione (GSH) metabolism such as γ-glutamyl cysteine ligase and various GSH transferases. |
| Report any problems that might have appeared and any solutions: | BLAST results indicate limited homology to human genes, but the entire sequence protein sequence is only 582 amino acids. eRNAi search results produced 5 potential probes for this gene. Only the best one (50% specificity, 45% efficiency and primer3 ranking of 2) is reported here. |
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