Worm gene name: |
lmn-1
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Worm sequence name: |
DY3.2
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Related human gene: |
lamin A
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Associated human disease: |
Hutchinson-Gilford progeria syndrome
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People involved in this project: |
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Left primer sequence: |
aaatcgaagagatgcgtgct
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Right primer sequence: |
gcgcctcctgagtaagattg
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Size of PCR product: |
408
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Brief description: |
LMN-1 encodes the sole C. elegans nuclear lamin; LMN-1 protein is essential for the nuclear envelope localization of emerin (EMR-1) protein during early development. Disruption of the orthologous human gene LMNA, which produces the nuclear scaffolding protein lamin A,leads to cellular instability which causes premature aging seen in progeria.
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Report any problems that might have appeared and any solutions: |
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