|Worm gene name:||egl-15|
|Worm sequence name:||F58A3.2|
|Related human gene:||FGRF3|
|Associated human disease:||Achondroplasia|
|People involved in this project:||
|Left primer sequence:||atggcgaatgccactttaac|
|Right primer sequence:||ggatccgaatcaacctcgta|
|Size of PCR product:||410|
|Brief description:|| Achondroplasia is an autosomal dominant disorder characterized by abnormal bone growth that results in short stature with disproportionately short arms and legs, and a large head Intelligence and life span are usually normal.
Achondroplasia is associated with a defect in the FGFR3 gene. 99% off affected individuals exhibit mutations in the FGFR3 gene. A significant number of affected individuals result from spontaneous mutations of this gene. Using the NCBI web page I located a homologous gene in C. elegans(egl-15) and developed primers using the E-RNAi web page. I have not had time to go any further at this point.
|Report any problems that might have appeared and any solutions:|