Worm gene name: |
emb-9
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Worm sequence name: |
K04H4.1
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Related human gene: |
Collagen, type II, Alpha -1
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Associated human disease: |
SPONDYLOEPIPHYSEAL DYSPLASIA CONGENITA
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People involved in this project: |
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Left primer sequence: |
gacaatccggaagagatgga
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Right primer sequence: |
ggaagtcctggtgatcctga
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Size of PCR product: |
388
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Brief description: |
emb-9 encodes the alpha-1 chain of Type IV basement membrane collagen most closely equivalent to human COL4A1 (OMIM:120130) on the basis of biological function; EMB-9 forms heterotrimeric Type IV collagen with LET-2, the alpha-2-like chain, and is required for the assembly and/or secretion of LET-2; EMB-9 is essential for embryonic morphogenesis, particularly epidermal elongation, and for larval development; EMB-9 is expresed primarily by body wall muscles and some somatic cells of the gonad and is detected in nearly all basement membranes.
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Report any problems that might have appeared and any solutions: |
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