Worm gene name:  Y11B2A.8
Worm sequence name:  Y11B2A.8
Related human gene:  PRKAG2;062743
Associated human disease:  Wolff-Parkinson-White Syndrome
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Left primer sequence:  caccaatcggtgaacttgtg
Right primer sequence:  agacgtgtgccacgtgtaaa
Size of PCR product:  527
Brief description:  WPW can be caused by a mutation in the gamma-2 regulatory subunit of AMP-activated protein kinase. Features: short PR interval and prolonged QRS on EKG; slurred upstroke of the R wave called a delta wave; causng paroxysmal supraventricular tachycardia. Gene map locus 7q36. NCBI #NP_001035723 AMP-activated kinase gamma 2 subunit isoform C. Worm sequence Y11B2A.8 is orthologous to the human gene AMP-activated protein kinase gamma subunit (PRKAG2:OMIM 602743), which when mutated leads to disease.
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08-22-08: Silencing Genes Workshop, Austin CC. I attempted to insert prepared primer into vector/bacteria but was unsuccessful at preparing vector.
Posted by Linda Allen on 2008-08-22 13:21:54