| Worm gene name: | mdf-2 |
| Worm sequence name: | Y69A2AR.30 |
| Related human gene: | MAD2L1 |
| Associated human disease: | MITOTIC ARREST-DEFICIENT 2, S. CEREVISIAE, HOMOLOG OF MAD2, S. CEREVISIAE, HOMOLOG OF |
| People involved in this project: |
|
| Left primer sequence: | cagatttcggccttaacagc |
| Right primer sequence: | gcagctttgagccagttttc |
| Size of PCR product: | 366 |
| Brief description: | mdf-2 encodes the C. elegans ortholog of the Mad2p spindle assembly checkpoint protein; mdf-2 activity is essential for regulation of the anaphase-promoting complex (APC) during oocyte meiosis I as well as for normal brood size, growth rates, and embryonic, larval, and vulval development; in addition, mdf-2 is essential for mitotic spindle checkpoint activity in response to anoxia, in which microscopically visible movement ceases and cell cycle progression reversibly arrests; by genetic analyses and comparison to studies in budding yeast, MDF-2 likely negatively regulates APC activity by inhibiting the activity of the FZY-1/CDC20p APC co-activator. |
| Report any problems that might have appeared and any solutions: | |
