| Worm gene name: | pdr-1 |
| Worm sequence name: | K08E3.7 |
| Related human gene: | PARK2 |
| Associated human disease: | Early-Onset Parkinson's Disease |
| People involved in this project: |
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| Left primer sequence: | tgtacctcgtgtggaatgga |
| Right primer sequence: | caatgtaacttcagacacaccg |
| Size of PCR product: | 172 |
| Brief description: | Although there are multiple genes in humans that cause Parkinson's symptoms, the PARK2 gene (also known as parkin gene) is responsible for causing the Early-Onset Parkinson's symptoms (onset < 40 years old). Common symptoms between Early-Onset Parkinson's and Classical include bradykinesia, rigidity, and tremor. However, the two are otherwise quite different. Early-Onset can begin as early as in childhood, with symptoms such as a difficulty in walking far distances. A deletion of the PARK2 gene causes Early-Onset Parkinson's.
When comparing the human PARK2 gene to the C. elegans pdr-1 gene, there are 128/456 (28%) identities, 190/456 (41%) positives, and 91/456 (19%) gaps. PARK2's amino acid sequence is: "MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV" |
| Report any problems that might have appeared and any solutions: | None currently known |
